Turk Arch Otolaryngol Online 40(1) 2002; 13-16 (Abstract)

				Online ISSN: 1303-6289 Print ISSN: 0304-4793
				Published Online: April 1, 2002

Turkish Archives of Otolaryngology 2002; 40(1): 13-16 Abstract

Full Text in Turkish [PDF] 214 KB

Evaluation of Efficacy of Nasal Sprays Containing Mometasone Furoate and Azelastine Hydrochloride in the Management of Allergic Rhinitis

Allerjik Rinit Tedavisinde Mometazon Furoat ile Azelastin Hidroklorür İçeren Nazal Spreylerin Etkinliklerinin Karşılaştırılması

Kemal Görür, Cengiz Özcan, Murat Ünal, Derya Ümit Talas, Serkan Kılınç

Mersin University, Faculty of Medicine, Department of ENT, Mersin, Turkey

Key Words

Allergic rhinitis, topical nasal steroid, topical antihistamines, diagnosis

Abstract

Objectives: To evaluate and compare the efficacy of mometasone furoate and azelastine nasal sprays in allergic rhinitis.

Materials and Methods: Ninety two patients with sneezing, nasal obstruction and rhinorrhea symptoms diagnosed as allergic rhinitis by physical examination, skin and blood test were included in this study. Forty-six patients (Group I) were treated with mometasone furoate, in the other forty-six patients (Group II) were treated with azelastine hydrochloride nasal sprays. The effect of administered treatment on sneezing, nasal congestion, concha edema and rhinorrhea were compared statistically.

Results: 60.8% (58 patients) of study group had perennial allergic rhinitis. The most common complaint of patients was nasal obstruction. Allergens were dust mite in 69 patients (75%). In the control of patients on the 5, 10 and 30th days, statistically significant improvement was observed in Group I versus Group II (p<0.005). Statistically significant relief of sneezing, rhinorrhea and nasal pruritus from seasonal allergic rhinitis in the Group II (p<0.005).

Conclusion: In this study, the mometasone furoate nasal sprays was observed superior to the azelastine sprays according to resolution of complaints and signs of allergic rhinitis patients. On the other hand, especially in the treatment of complaints of patients with seasonal allergic rhinitis such as sneezing, rhinorrhea and pruritus early and meaningful relief was observed by azelastine treatment.

		Accepted: December 14, 2001
		Correspondence:	Kemal Görür, MD Fatih Mah. Babil Cad. Girne Sitesi D Blok No: 1 Mezitli, Mersin - Türkiye, Phone: (0324) 337 43 25, 337 43 00, Fax: (0324) 337 43 05 e-mail: dkgorur@hotmail.com